PhD-Student (gn*) Life Sciences, Inflammation Research
Eckdaten der angebotenen Stelle
| Arbeitgeber | Universitätsklinikum Münster |
| Postleitzahl | |
| Ort | Münster |
| Bundesland | North Rhine-Westphalia |
| Gepostet am | 05.05.2025 |
| Remote Option? | - |
| Homeoffice Option? | - |
| Teilzeit? | |
| Vollzeit? | - |
| Ausbildungsstelle? | - |
| Praktikumsplatz? | - |
| Unbefristet? | |
| Befristet? | - |
Stellenbeschreibung
PhD-Student (gn*) Life Sciences, Inflammation ResearchFixed-term of 3 years | Part-time with 65% (25 hours/week) | Salary according to TV-L E13 | The Institute for Experimental Pathology | Job ID: 10417
We are UKM. We have a clear social mission and, with our focus on healthcare, research, and teaching, we bear a unique responsibility.
To meet our high standards every day, we are looking forward to your scientific expertise in the Institute for Experimental Pathology based at the Center for Inflammation Research at the University of Münster - ideally with you on board!
PROJECT TITLE:
Investigating the Interaction between Infection and Vascular Inflammation
THE INSTITUTE AND PROJECT:
The Institute for Experimental Pathology is led by Oliver Soehnlein. His work focuses on the importance of neutrophils in acute and chronic inflammation with specific focus on atherosclerosis and its complications such as myocardial infarction and neointimal hyperplasia (Soehnlein et al., Sci Transl Med, 2011; Ferraro et al., JACC, 2019; Silvestre-Roig et al., Nature, 2019; Schumski et al., Circulation, 2021). Central to the group's mechanistic understanding of how neutrophils promote chronic, sterile inflammation is its interplay with antigen presenting cells, predominantly macrophages (Soehnlein & Lindbom, Nat Rev Immunol, 2010; Soehnlein et al., Nat Rev Immunol, 2017; Soehnlein & Libby, Nat Rev Drug Discov, 2021). It is a key feature of the group's work to unveil thus far unknown mechanistic details which are then translated towards innovative preclinical intervention strategies (Alard et al., Sci Transl Med, 2015; Silvestre-Roig et al., Nature, 2019), some of which have been patented. Our group is highly interdisciplinary, international, and uses state-of-the-art techniques spanning a broad range from immunology, cell and molecular biology, (spatial) single cell omics and bioinformatics. The project is embedded in national and international consortia on cardiovascular inflammation and funded by the Deutsche Forschungsgemeinschaft.
Your Tasks
Design and conduct experiments utilizing state-of-the-art approaches such as:
Animal models of infection and atherosclerosis
Flow cytometric analysis of immune cell populations from murine tissues using full spectrum flow cytometry
Immunohistological staining and imaging of tissue sections using multiplexed immunohistochemistry
Biochemical assays for cytokines and other inflammatory mediators
Collaborate closely with colleagues across disciplines to integrate findings into a comprehensive model of atherosclerosis pathophysiology
Analyze data, interpret results, and present conclusions through high-quality publications, presentations, and reports
Contribute to manuscript preparation
Participate actively in departmental seminars, workshops, and conferences
What we expect:
MSc degree in Biological Sciences
Strong background in immunology and/or vascular biology
Expertise in one or more of the following areas:
Flow cytometry-based phenotyping and sorting
Immunofluorescence microscopy and histopathological evaluation
Statistical programming languages like R or Python
Good communication skills in English; proficiency in German desirable but not required
Willingness to work independently while contributing effectively to collaborative projects
Willingness to participate in ongoing training programs to enhance expertise and stay up -to -date with latest methodologies
What we offer:
Benefits package including health insurance, pension plan, and family support services
Access to world-class infrastructure, equipment, and resources
Opportunities for professional growth, networking, and international collaboration
Supportive environment fostering creativity, innovation, and interdisciplinary exchange
For inquiries, please contact: Oliver Soehnlein, T 0251 83-53001
Apply now via our career portal until 02.06.2025 including:
Cover letter highlighting relevant experience, interests, and career goals (max. 2 pages)
Curriculum Vitae with publication list and academic record
Contact details for two referees familiar with your scientific achievements
BENEFITS
Exciting Projects
Professional Development and Training
Interdisciplinary Collaboration
Part of Research Innovation
Additional Benefits
Exciting Projects
Professional Development and Training
Interdisciplinary Collaboration
Part of Research Innovation
Additional Benefits
(*gn=gender neutral)
The University Hospital of Münster is one of the leading hospitals in Germany. Such a position cannot be achieved by size and medical successes alone. The individual commitment counts above all. We need your commitment so that even with little things we can achieve great things for our patients. There are many possibilities open for you so that you may develop with them.
Universitätsklinikum Münster
Albert-Schweitzer-Campus 1, Gebäude D5
48149 Münster
www.ukm.de
We are UKM. We have a clear social mission and, with our focus on healthcare, research, and teaching, we bear a unique responsibility.
To meet our high standards every day, we are looking forward to your scientific expertise in the Institute for Experimental Pathology based at the Center for Inflammation Research at the University of Münster - ideally with you on board!
PROJECT TITLE:
Investigating the Interaction between Infection and Vascular Inflammation
THE INSTITUTE AND PROJECT:
The Institute for Experimental Pathology is led by Oliver Soehnlein. His work focuses on the importance of neutrophils in acute and chronic inflammation with specific focus on atherosclerosis and its complications such as myocardial infarction and neointimal hyperplasia (Soehnlein et al., Sci Transl Med, 2011; Ferraro et al., JACC, 2019; Silvestre-Roig et al., Nature, 2019; Schumski et al., Circulation, 2021). Central to the group's mechanistic understanding of how neutrophils promote chronic, sterile inflammation is its interplay with antigen presenting cells, predominantly macrophages (Soehnlein & Lindbom, Nat Rev Immunol, 2010; Soehnlein et al., Nat Rev Immunol, 2017; Soehnlein & Libby, Nat Rev Drug Discov, 2021). It is a key feature of the group's work to unveil thus far unknown mechanistic details which are then translated towards innovative preclinical intervention strategies (Alard et al., Sci Transl Med, 2015; Silvestre-Roig et al., Nature, 2019), some of which have been patented. Our group is highly interdisciplinary, international, and uses state-of-the-art techniques spanning a broad range from immunology, cell and molecular biology, (spatial) single cell omics and bioinformatics. The project is embedded in national and international consortia on cardiovascular inflammation and funded by the Deutsche Forschungsgemeinschaft.
Your Tasks
Design and conduct experiments utilizing state-of-the-art approaches such as:
Animal models of infection and atherosclerosis
Flow cytometric analysis of immune cell populations from murine tissues using full spectrum flow cytometry
Immunohistological staining and imaging of tissue sections using multiplexed immunohistochemistry
Biochemical assays for cytokines and other inflammatory mediators
Collaborate closely with colleagues across disciplines to integrate findings into a comprehensive model of atherosclerosis pathophysiology
Analyze data, interpret results, and present conclusions through high-quality publications, presentations, and reports
Contribute to manuscript preparation
Participate actively in departmental seminars, workshops, and conferences
What we expect:
MSc degree in Biological Sciences
Strong background in immunology and/or vascular biology
Expertise in one or more of the following areas:
Flow cytometry-based phenotyping and sorting
Immunofluorescence microscopy and histopathological evaluation
Statistical programming languages like R or Python
Good communication skills in English; proficiency in German desirable but not required
Willingness to work independently while contributing effectively to collaborative projects
Willingness to participate in ongoing training programs to enhance expertise and stay up -to -date with latest methodologies
What we offer:
Benefits package including health insurance, pension plan, and family support services
Access to world-class infrastructure, equipment, and resources
Opportunities for professional growth, networking, and international collaboration
Supportive environment fostering creativity, innovation, and interdisciplinary exchange
For inquiries, please contact: Oliver Soehnlein, T 0251 83-53001
Apply now via our career portal until 02.06.2025 including:
Cover letter highlighting relevant experience, interests, and career goals (max. 2 pages)
Curriculum Vitae with publication list and academic record
Contact details for two referees familiar with your scientific achievements
BENEFITS
Exciting Projects
Professional Development and Training
Interdisciplinary Collaboration
Part of Research Innovation
Additional Benefits
Exciting Projects
Professional Development and Training
Interdisciplinary Collaboration
Part of Research Innovation
Additional Benefits
(*gn=gender neutral)
The University Hospital of Münster is one of the leading hospitals in Germany. Such a position cannot be achieved by size and medical successes alone. The individual commitment counts above all. We need your commitment so that even with little things we can achieve great things for our patients. There are many possibilities open for you so that you may develop with them.
Universitätsklinikum Münster
Albert-Schweitzer-Campus 1, Gebäude D5
48149 Münster
www.ukm.de